Recursive Partitioning Analysis of Systemic Therapy after Radiotherapy in Patients with Brain Metastases

<b><i>Purpose:</i></b> The purpose of this study was to identify factors associated with the initiation or continuation systemic treatment after brain irradiation. outcome interest a utilization rate at least 75%, given that active extracranial disease is common in patients metastases. If left untreated, limits survival, regardless successful local In context, therapy has been shown improve e.g., whole-brain radiotherapy. <b><i>Patients and Methods:</i></b> included 185 disease, 60% whom received therapy. <b><i>Results:</i></b> Survival from start irradiation longest who additional immune checkpoint inhibitors, endocrine treatment, anti-HER-2 drugs. After uni- multivariate analyses, Eastern Cooperative Oncology Group performance status (PS) selected as first prediction criterion recursive partitioning analysis (RPA) decision tree analysis. RPA for PS 0–1, but 2 had lower rates (maximum 60–70%, disease-dependent impact age LabBM score [blood test results]). highest were observed (1) 0 (2) those breast cancer, small-cell lung adenocarcinoma 1. <b><i>Conclusions:</i></b> These results inform multidisciplinary discussion planning scenario simultaneous intra-